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- Title
Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota.
- Authors
Hosomi, Koji; Saito, Mayu; Park, Jonguk; Murakami, Haruka; Shibata, Naoko; Ando, Masahiro; Nagatake, Takahiro; Konishi, Kana; Ohno, Harumi; Tanisawa, Kumpei; Mohsen, Attayeb; Chen, Yi-An; Kawashima, Hitoshi; Natsume-Kitatani, Yayoi; Oka, Yoshimasa; Shimizu, Hidenori; Furuta, Mari; Tojima, Yoko; Sawane, Kento; Saika, Azusa
- Abstract
The gut microbiome is an important determinant in various diseases. Here we perform a cross-sectional study of Japanese adults and identify the Blautia genus, especially B. wexlerae, as a commensal bacterium that is inversely correlated with obesity and type 2 diabetes mellitus. Oral administration of B. wexlerae to mice induce metabolic changes and anti-inflammatory effects that decrease both high-fat diet–induced obesity and diabetes. The beneficial effects of B. wexlerae are correlated with unique amino-acid metabolism to produce S-adenosylmethionine, acetylcholine, and l-ornithine and carbohydrate metabolism resulting in the accumulation of amylopectin and production of succinate, lactate, and acetate, with simultaneous modification of the gut bacterial composition. These findings reveal unique regulatory pathways of host and microbial metabolism that may provide novel strategies in preventive and therapeutic approaches for metabolic disorders. Here, the authors inversely associate Blautia wexlerae with obesity and type 2 diabetes mellitus in humans and further show that administration of B. wexlerae to mice decrease both high-fat diet–induced obesity and diabetes via modulating gut microbial metabolism.
- Subjects
ORAL drug administration; TYPE 2 diabetes; GUT microbiome; JAPANESE people; MICROBIAL metabolism; LACTATES; BACTERIAL metabolism
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-32015-7