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- Title
Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma.
- Authors
Seo, Jimyung; Kim, HyunSeok; Min, Kyoung Il; Kim, Changgon; Kwon, Yongsoo; Zheng, Zhenlong; Kim, Yusung; Park, Hyung-Soon; Ju, Young Seok; Roh, Mi Ryung; Chung, Kee Yang; Kim, Joon
- Abstract
Acral melanoma commonly occurs in areas that are not exposed to much sunlight, such as the sole of the foot. Little is known about risk factors and mutational processes of plantar acral melanoma. Nuclear envelope rupture during interphase contributes to genome instability in cancer. Here, we show that the nuclear and micronuclear membranes of melanoma cells are frequently ruptured by macroscopic mechanical stress on the plantar surface due to weight-bearing activities. The marginal region of plantar melanoma nodules exhibits increased nuclear morphological abnormalities and collagen accumulations, and is more susceptible to mechanical stress than the tumor center. An increase in DNA damage coincides with nuclear membrane rupture in the tumor margin. Nuclear envelope integrity is compromised by the mechanosensitive transcriptional cofactor YAP activated in the tumor margin. Our results suggest a mutagenesis mechanism in melanoma and explain why plantar acral melanoma is frequent at higher mechanical stress points. Acral melanoma affects the soles of the feet but the etiology is unknown. Here, the authors show that melanoma cells implanted into the foot pad of mice and exposed to mechanical stress show features of nuclear rupture, DNA damage, and Yap activation.
- Subjects
NUCLEAR membranes; YAP signaling proteins; MELANOMA; DNA damage; GENOMES; FOOT; ROOT-tubercles
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-29925-x