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- Title
Prognostic Biomarkers and EBV Infection Research in Diffuse Large B-Cell Lymphoma of the Palatine Tonsils.
- Authors
Marques, Marinho; Luz, Estela; Humme, Michael; Gračas Vieira, Maria das; Bahia, Regina Célia; Oliveira, Maria Cristina; Netto, Eduardo Martins; Luz, Ivana; Aráujo, Iguaracyra
- Abstract
Diffuse large B-cell lymphoma represents approximately 30%-40% of all diagnoses of non-Hodgkin's Lymphoma and may represent up to 80% of all lymphomas that arise in the palatine tonsils. Several studies have attempted to correlate clinical, laboratorial, and tissue factors with the prognosis of the lymphomas, such as the International Prognostic Index, the tissue expression of some proteins, and the lymphocyte count at the time of diagnosis, as well as to correlate Epstein-Barr virus (EBV) infection with worse prognoses. Patients with palatine tonsil DLBCL, from Salvador, Bahia, Brazil, were studied in order to identify prognostic factors. Twenty-four patients with DLBCL were studied. The factors that negatively influenced the patients' survival rates were the lymphocyte count at the time of diagnosis <1.000/mm3 and the Bcl-2 protein expression. There was no CD5 expression in these lymphomas, and neither was there an association with EBV infection.
- Subjects
BRAZIL; B cell lymphoma; EPSTEIN-Barr virus; FISHER exact test; IMMUNOHISTOCHEMISTRY; SURVIVAL analysis (Biometry); SURVIVAL; TONSILS; TUMOR markers; TUMOR classification; U-statistics; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; PROGNOSIS
- Publication
ISRN Oncology, 2012, p1
- ISSN
2090-5661
- Publication type
Article
- DOI
10.5402/2012/652682