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- Title
Bioinspired Electropun Fibrous Materials Based on Poly-3-Hydroxybutyrate and Hemin: Preparation, Physicochemical Properties, and Weathering.
- Authors
Tyubaeva, Polina M.; Varyan, Ivetta A.; Zykova, Anna K.; Yarysheva, Alena Yu.; Ivchenko, Pavel V.; Olkhov, Anatoly A.; Arzhakova, Olga V.
- Abstract
The development of innovative fibrous materials with valuable multifunctional properties based on biodegradable polymers and modifying additives presents a challenging direction for modern materials science and environmental safety. In this work, high-performance composite fibrous materials based on semicrystalline biodegradable poly-3-hydroxybutyrate (PHB) and natural iron-containing porphyrin, hemin (Hmi) were prepared by electrospinning. The addition of Hmi to the feed PHB mixture (at concentrations above 3 wt.%) is shown to facilitate the electrospinning process and improve the quality of the electrospun PHB/Hmi materials: the fibers become uniform, their average diameter decreases down to 1.77 µm, and porosity increases to 94%. Structural morphology, phase composition, and physicochemical properties of the Hmi/PHB fibrous materials were studied by diverse physicochemical methods, including electronic paramagnetic resonance, optical microscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy, elemental analysis, differential scanning calorimetry, Fourier-transformed infrared spectroscopy, mechanical analysis, etc. The proposed nonwoven Hmi/PHB composites with high porosity, good mechanical properties, and retarded biodegradation due to high antibacterial potential can be used as high-performance and robust materials for biomedical applications, including breathable materials for wound disinfection and accelerated healing, scaffolds for regenerative medicine and tissue engineering.
- Subjects
POLYCAPROLACTONE; HEMIN; POLY-beta-hydroxybutyrate; POLYHYDROXYBUTYRATE; MATERIALS science; PARAMAGNETIC resonance; DIFFERENTIAL scanning calorimetry; FIBROUS composites
- Publication
Polymers (20734360), 2022, Vol 14, Issue 22, p4878
- ISSN
2073-4360
- Publication type
Article
- DOI
10.3390/polym14224878