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- Title
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations.
- Authors
Weiping Zou; Wolchok, Jedd D.; Lieping Chen
- Abstract
The article discusses the study on the PD-L1 (B7-H1) and PD-1 pathway blockade for cancer treatment. The PD-L1 (B7-H1) and PD-1 pathway blockade is reportedly a promising therapy for different types of cancers. Also explored are the blockade's mechanisms of action, their roles in therapeutic responses, and various combinations with PD pathway blockade and their rationale for treatment.
- Subjects
CANCER treatment; IMMUNOTHERAPY; BIOMARKERS; THERAPEUTICS; ANTINEOPLASTIC agents
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 328, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aad7118