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- Title
Interferon-l restricts West Nile virus neuroinvasion by tightening the blood-brain barrier.
- Authors
Lazear, Helen M.; Daniels, Brian P.; Pinto, Amelia K.; Huang, Albert C.; Vick, Sarah C.; Doyle, Sean E.; Gale Jr., Michael; Klein, Robyn S.; Diamond, Michael S.
- Abstract
The article focuses findings of a study on role of interferon-lambda in inhibiting West Nile virus neuroinvasion. It states that a recombinant interferon-gamma and mice lacking the interferon-lambda receptor were used to evaluate the effect of the interferon on infection with West Nile virus, and mentions that treatment of mice with pegylated interferon resulted in decreased blood-brain barrier permeability. It infers an indirect antiviral function of the interferon in the inhibition.
- Subjects
INTERFERONS; WEST Nile virus; BLOOD-brain barrier; WEST Nile fever prevention; ANTIVIRAL agents; THERAPEUTIC use of interferons; PHYSIOLOGY
- Publication
Science Translational Medicine, 2015, Vol 7, Issue 284, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaa4304