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- Title
Do mesothelin/MUC16 interactions facilitate adenocarcinoma metastases to intracranial meningiomas?
- Authors
Johnson, Mahlon D.
- Abstract
Background: Meningiomas have been shown to express mesothelin, a high affinity binding site for MUC16, a transmembrane protein on adenocarcinoma cells. The mechanisms underlying adenocarcinoma metastases to meningiomas may provide insight into tumortotumor metastases and adenocarcinoma metastases to leptomeningeal cells. Methods: Two meningiomas containing metastases from adenocarcinomas were identified and evaluated immunohistochemically for the expression and localization of mesothelin and MUC16. Results: Both meningiomas show extensive mesothelin immunoreactivity, and the adenocarcinomas metastatic to the meningiomas show mesothelin and MUC16 immunoreactivity at the interface with meningioma. Conclusions: Interactions between MUC16 and/or mesothelin on the cell membrane of adenocarcinoma cells with mesothelin on meningioma cells may facilitate adenocarcinoma metastases to meningiomas and possibly the leptomeninges.
- Subjects
MENINGIOMA; ADENOCARCINOMA; MESOTHELIN; MEMBRANE proteins; MENINGEAL cancer
- Publication
Surgical Neurology International, 2016, Vol 7, p1
- ISSN
2229-5097
- Publication type
Article
- DOI
10.4103/21527806.196367