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- Title
A fresh look into the pathophysiology of ischemia-induced complications in patients with chronic kidney disease undergoing hemodialysis.
- Authors
Honore, Patrick M.; Jacobs, Rita; Waele, Elisabeth De; Van Gorp, Viola; De Regt, Jouke; Joannes-Boyau, Olivier; Boer, Willem; Spapen, Herbert D.
- Abstract
Recent case reports of acute esophageal necrosis in patients with chronic kidney disease (CKD) undergoing hemodialysis encouraged us to look beyond hypoperfusion/ischemia as a sole explanation for this dramatic complication. At least three intriguing pathways, ie, accumulation of protein-bound toxins, endotoxin translocation, and altered mucosal defense mechanisms, have been proposed to explain the inherent susceptibility of CKD patients to developing ischemia-related and cardiovascular events. Interestingly, all the proposed pathways can be potentially antagonized or attenuated. At present, however, it is not known whether one pathway predominates or if any interaction exists between these pathways. More solid experimental and clinical data are warranted to acquire a better insight into the complex pathogenesis of CKD-associated ischemia.
- Subjects
PATHOLOGICAL physiology; ISCHEMIA; KIDNEY diseases; HEMODIALYSIS patients; MICROBIAL metabolism; PATIENTS
- Publication
International Journal of Nephrology & Renovascular Disease, 2015, Vol 8, p25
- ISSN
1178-7058
- Publication type
Article
- DOI
10.2147/IJNRD.S75960