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- Title
Design of drug molecule-based structure for SMAD3 protein and its in silico investigations of leukemia utilizing bioinformatics software.
- Authors
Manikandan, A.; Jayalakshmi, T.; Babu, P. B. Ramesh; Priya, R.
- Abstract
Introduction: The current study mainly focus on the drug designing of proteins responsible in producing leukemia and the specific inhibitors were identified. Materials and Methods: PTHrP emerged to be the best inhibitor for the protein SMAD3. The precise reason for it was its docking energy which was the lowest (docked energy = −29.73), among all other inhibitors used. Hence, the conclusion is that SMAD3 is the best inhibitor, for SMAD3. Results and Discussion: Hence, the task was completed successfully. There are many reasons and factors responsible for induction of cancer. Conclusion: Leukemia is a type of cancer in blood or bone marrow and is characterized by an irregular proliferation of white blood cells.
- Subjects
DRUG design; BIOINFORMATICS software; PROTEIN structure; BONE marrow cancer; LEUKEMIA
- Publication
Drug Invention Today, 2019, Vol 11, Issue 7, p1680
- ISSN
0975-7619
- Publication type
Article