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- Title
Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response.
- Authors
Francica, Paola; Rottenberg, Sven
- Abstract
Editorial summary: Inhibitors of poly(ADP-ribose) polymerase (PARPi) have entered the clinic for the treatment of patients with cancers that lack homology-directed DNA repair, but drug resistance remains a clinical hurdle. Recent advances in the identification of PARPi resistance mechanisms have yielded a better understanding of DNA end protection and the relevance of endogenous poly(ADP-ribose) glycohydrolase, highlighting new vulnerabilities.
- Subjects
POLY(ADP-ribose) polymerase; DRUG resistance; CANCER treatment; DNA damage; HOMOLOGY (Biology)
- Publication
Genome Medicine, 2018, Vol 10, Issue 1, pN.PAG
- ISSN
1756-994X
- Publication type
Article
- DOI
10.1186/s13073-018-0612-8