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- Title
Management of Drug Therapy for Leptomeningeal Metastasis of Sensitive Driver Gene Positive Non-small Cell Lung Cancer.
- Authors
Zhiqin LU; Jing CAI; Zhimin ZENG; Anwen LIU
- Abstract
Leptomeningeal metastasis (LM) is one of the serious complications of advanced non-small cell lung cancer (NSCLC), although the incidence is not high, the clinical symptoms are severe and the prognosis is poor. LM is prone to occur in patients with positive driver gene than negative. At present, the treatment of LM mainly includes molecular targeted therapy, systemic chemotherapy, whole brain radiotherapy, intrathecal chemotherapy and immunotherapy. Although there are many treatments, the efficacy of LM is still unsatisfactory. This article reviews the drug therapy of sensitive driver gene positive NSCLC LM.
- Subjects
LUNG cancer complications; LUNG cancer &; genetics; CANCER chemotherapy; IMMUNOTHERAPY; MENINGEAL cancer; METASTASIS; DISEASE incidence; DISEASE risk factors
- Publication
Chinese Journal of Lung Cancer, 2020, Vol 23, Issue 8, p710
- ISSN
1009-3419
- Publication type
Article
- DOI
10.3779/j.issn.1009-3419.2020.102.18