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- Title
Increased brain injury and vascular leakage after pretreatment with p38-inhibitor SB203580 in transient ischemia.
- Authors
Lennmyr, F.; Ericsson, A.; Gerwins, P.; Ahlström, H.; Terént, A.
- Abstract
Lennmyr F, Ericsson A, Gerwins P, Ahlström H, Terént A. Increased brain injury and vascular leakage after pretreatment with p38-inhibitor SB203580 in transient ischemia. Acta Neurol Scand DOI:10.1046/j.1600-0404.2003.00129.x © Blackwell Munksgaard 2003. Focal cerebral ischemia activates intracellular signaling pathways including the mitogen-activated protein kinase p38, which may be involved in the process of ischemic brain injury. In this study, the effect of pretreatment with the p38-inhibitor SB203580 on infarct size and blood–brain barrier (BBB) breakdown was investigated with magnetic resonance imaging (MRI). Rats were given SB203580 ( n = 6) or vehicle ( n = 6) in the right lateral ventricle prior to transient (90 min) middle cerebral artery occlusion (MCAO) on the left side. The rats were examined with serial MRI during MCAO, at reperfusion and after 1 and 4 days. The mean infarct size on T2-weighted images after 1 day was significantly higher in the SB203580-treated group than in controls (300 ± 95 mm3 vs 126 ± 75 mm3; P < 0.01). Vascular gadolinium leakage, indicating BBB breakdown, was significantly larger in the SB203580-treated group than in controls after 1 day (median leakage score 18.5; range 15–21 vs 6.5; 4–17; P < 0.05) and 4 days (11; 6–15 vs 3.5; 1–9; P < 0.05), although no significant difference was seen initially. Pretreatment with SB203580 may aggravate ischemic brain injury and cerebral vascular leakage in the present model of transient ischemia.
- Subjects
CEREBRAL ischemia; BRAIN injuries; PROTEIN kinases; MAGNETIC resonance imaging; GADOLINIUM; RESEARCH
- Publication
Acta Neurologica Scandinavica, 2003, Vol 108, Issue 5, p339
- ISSN
0001-6314
- Publication type
Article
- DOI
10.1034/j.1600-0404.2003.00129.x