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- Title
THE CORRELATION BETWEEN THE PERIPLAQUE FAT AND THE VULNERABILITY MARKERS IN A PATIENT WITH STABLE CORONARY ARTERY DISEASE.
- Authors
Alina-Cristina, Muntean; Oana-Adriana, Matei; Olariu, Simina-Otilia; Alexandra, Muscalu Ana-Maria; Pîslariu, Gabriela; Theodora, Benedek; Imre, Benedek
- Abstract
Background: The periplaque fat, a part adipose tissue surrounding the coronary artery, increases the risk of an acute event through its proinflammatory activity. Objective: The aim of this study was to determine the periplaque adipose tissue effects located near a vulnerably coronary plaque. Material and methods: We inrolled 77 patients with specific coronary artery disease symptoms, undergoing a 128 multislice CTCA, with minimum one of 50% stenosis. After taking into consideration the volume and distribution of the periplaque fat, epicardial fat, vascular indices and plaque related parameters , we classified the study population into two groups: group 1- one marker of plaque vulnerability and group 2- more than one marker of plaque vulnerability. Results: The mean age was 62+- 11 years old. The patients enrolled in group 2 had remarkably higher volume of periplaque fat than the ones with only one or two vulnerability markers (147.5 ± 71.74 mm3 vs. 207.7 ± 108.9 mm3, p = 0.006). It is also notable that as the periplaque fat volume increases, some atheroma parameters such as: non calcified volume ( p <0.0001), lipid rich volume (p = 0.005), and fibro fatty volume (p <0.0001) will also get higher. We also observed that there is no significant correlation between the volume of the periplaque adipose tissue and the calcified volume (p = 0.9091) or the total volume of the lesion (p = 0.4). Conclusions: The periplaque fat located round of a coronary stenosis is related to a higher level of vulnerability on CTCA.
- Subjects
ADIPOSE tissue diseases; CORONARY disease; FAT; ADIPOSE tissues; CORONARY artery stenosis; SYMPTOMS
- Publication
Acta Medica Marisiensis, 2019, Vol 65, p17
- ISSN
2068-3324
- Publication type
Article