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- Title
Cardiovascular Actions of Endomorphin-2 in the Nucleus Tractus Solitarius
- Authors
Sapru, Hreday N.
- Abstract
Abstract: Cardiovascular effects of microinjections of endomorphin-2 into the medial subnucleus of the nucleus tractus solitarius (mNTS) were studied in adult, male, urethane-anesthetized, Wistar rats. Microinjections of endomorphin-2 into the mNTS elicited depressor and bradycardic responses via mu-opioid receptors. Similar microinjections of endomorphin-2 attenuated the carotid sinus and aortic baroreflex responses. Endomorphin-2 inhibits GABAergic mNTS neurons via mu-opioid receptors, causing disinhibition which results in excitation of secondary mNTS neurons. This effect causes depressor and bradycardic responses. Endomorphin-2 also inhibits glutamate release from baroreceptor terminals via mu-opioid receptors located on these terminals and attenuates baroreflex responses.
- Subjects
OPIOID peptides; MICROINJECTIONS; LABORATORY rats; OPIOID receptors; CAROTID sinus; BAROREFLEXES; GLUTAMIC acid
- Publication
Tzu Chi Medical Journal, 2008, Vol 20, Issue 2, p77
- ISSN
1016-3190
- Publication type
Article
- DOI
10.1016/S1016-3190(08)60015-4