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- Title
Stability and Change of Genetic and Environmental Effects on the Common Liability to Alcohol, Tobacco, and Cannabis DSM-IV Dependence Symptoms.
- Authors
Palmer, R.; Young, S.; Corley, R.; Hopfer, C.; Stallings, M.; Hewitt, J.
- Abstract
This study investigated the stability of genetic and environmental effects on the common liability to alcohol, tobacco, and cannabis dependence across adolescence and young adulthood. DSM-IV symptom counts from 2,361 adolescents were obtained using a structured diagnostic interview. Several sex-limited longitudinal common pathway models were used to examine gender differences in the magnitude of additive genetic (A), shared environment, and non-shared environmental effects over time. Model fitting indicated limited gender differences. Among older adolescents (i.e., age >14), the heritability of the latent trait was estimated at 0.43 (0.05, 0.94) during the first wave and 0.63 (0.21, 0.83) during the second wave of assessment. A common genetic factor could account for genetic influences at both assessments, as well as the majority of the stability of SAV over time [rA = 1.00 (0.55, 1.00)]. These results suggest that early genetic factors continue to play a key role at later developmental stages.
- Subjects
ALCOHOL; TOBACCO; CANNABIS (Genus); SYMPTOMS; ADULTS; GENDER differences (Psychology); LONGITUDINAL method; HERITABILITY; PHYSIOLOGY
- Publication
Behavior Genetics, 2013, Vol 43, Issue 5, p374
- ISSN
0001-8244
- Publication type
Article
- DOI
10.1007/s10519-013-9599-5