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- Title
Successful Treatment of Disseminated Nocardiosis Caused by Nocardia veterana in a Dog.
- Authors
Yaemsiri, S.; Sykes, J. E.
- Abstract
A 5‐year‐old male castrated Lhasa Apso cross was evaluated for a 1‐month history of inappetence, lethargy, gagging, and progressive right thoracic limb lameness. Synovial fluid analysis revealed nonseptic suppurative inflammation, and a diagnosis of immune‐mediated polyarthritis (IMPA) was made. After 3 months of treatment with prednisone and later cyclosporine, the dog developed multiple firm cutaneous and subcutaneous masses and a focal mass within the jejunum. Cultures of blood, urine, skin lesions, and the jejunal mass identified <italic>Nocardia veterana</italic> by matrix‐absorption laser desorption ionization‐time‐of‐flight mass spectrometry (MALDI‐TOF MS) and allowed for earlier identification of the organism compared to more traditional <italic>secA1</italic> gene sequencing. Immunosuppressive drug treatment was discontinued, and the dog was treated for 3 months by administration of trimethoprim‐sulfamethoxazole (TMS). No recurrence of clinical signs was reported 1 year later. This case report highlights the clinical utility of MALDI‐TOF MS, particularly for the rapid identification of slow‐growing, fastidious organisms.
- Subjects
NOCARDIOSIS; DOG diseases; VETERINARY therapeutics; NOCARDIA; LHASA apso; ACTINOMYCETALES; IMMUNOSUPPRESSION; SYNOVIAL fluid examination; THERAPEUTICS
- Publication
Journal of Veterinary Internal Medicine, 2018, Vol 32, Issue 1, p418
- ISSN
0891-6640
- Publication type
Case Study
- DOI
10.1111/jvim.14855