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- Title
Effectiveness of Influenza Vaccination in Preventing Hospitalization Due to Influenza in Children: A Systematic Review and Meta-analysis.
- Authors
Boddington, Nicki L; Pearson, Isabelle; Whitaker, Heather; Mangtani, Punam; Pebody, Richard G
- Abstract
This systematic review assesses the literature for estimates of influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza-associated hospitalization in children. Studies of any design to June 8, 2020, were included if the outcome was hospitalization, participants were 17 years or younger and influenza infection was laboratory-confirmed. A random-effects meta-analysis of 37 studies that used a test-negative design gave a pooled seasonal IVE against hospitalization of 53.3% (47.2–58.8) for any influenza. IVE was higher against influenza A/H1N1pdm09 (68.7%, 56.9–77.2) and lowest against influenza A/H3N2 (35.8%, 23.4–46.3). Estimates by vaccine type ranged from 44.3% (30.1–55.7) for live-attenuated influenza vaccines to 68.9% (53.6–79.2) for inactivated vaccines. IVE estimates were higher in seasons when the circulating influenza strains were antigenically matched to vaccine strains (59.3%, 48.3–68.0). Influenza vaccination gives moderate overall protection against influenza-associated hospitalization in children supporting annual vaccination. IVE varies by influenza subtype and vaccine type.
- Subjects
INFLUENZA prevention; HOSPITAL care evaluation; INFLUENZA vaccines; IMMUNIZATION; META-analysis; SYSTEMATIC reviews; TREATMENT effectiveness; CHILDREN
- Publication
Clinical Infectious Diseases, 2021, Vol 73, Issue 9, p1722
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciab270