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- Title
Anticonvulsive activity of duloxetine: A new choice for the epileptic patients with depression.
- Authors
Yi Wu; Yuping Huang; Mingxia Song; Zongping Zhang; Zhen Liang; Xianqing Deng
- Abstract
The aim of this study was to investigate the antiepileptic effects of duloxetine in the maximal electroshock test and convulsions induced by four compounds: Pentylenetetrazole, 3-mercaptopropionic acid, thiosemicarbazide, and bicuculline. Duloxetine exhibited moderate anticonvulsive activity with an ED50 (median effective dose) of 48.21 mg/kg in the maximal electroshock test in mice. The anticonvulsive action of duloxetine was also confirmed in chemicalinduced seizure tests, where this drug decreased tonic convulsions. Single administration of duloxetine (6.25-25 mg/kg) significantly increased the anticonvulsant effects of valproate, carbamazepine, and oxcarbazepine in the maximal electroshock test. Furthermore, pretreatment with thiosemicarbazide (an inhibitor of GABA synthesis enzyme) significantly increased the ED50 of duloxetine, suggesting the GABAergic system may contribute to the anticonvulsive action of duloxetine. These results support the use of duloxetine in the treatment of coexisting depression and epilepsy.
- Subjects
CARBAMAZEPINE; GABA; SEIZURES (Medicine); EPILEPSY
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2019, Vol 32, Issue 3, p997
- ISSN
1011-601X
- Publication type
Article