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- Title
Levan as a new additive for colon-specific films: A new approach in the use of exopolysaccharides in time-dependent free films (Aminoalkyl Methacrylate Copolymer RS).
- Authors
Freire dos Santos, Leandro; Gómez Pineda, Edgardo Alfonso; Pedrine Colabone Celligoi, Maria Antonia; Albuquerque Cavalcanti, Osvaldo
- Abstract
Time-dependent films, augmented with prebiotics, offer potential strategy for colon-specific controlled drug release. In this study, we produced films containing levan (L) and Aminoalkyl Methacrylate Copolymer RS (ER). Free films of ER combined with levan were produced by the casting process and characterized by the mobility of the polymeric matrix, hydration, differential scanning calorimetry (DSC) and thermogravimetry (TGA). The results of this study suggest that the exopolysaccharide levan can be used in combination with ER for colon specific materials. No evidence of incompatibilities between the levan and the synthetic polymer were detected, and levan improved the mobility of the polymeric matrix and the hydrophilicity of the system. Levan may have positively altered the density of the polymeric matrix, as visualized by thermal characterization. The endothermic decomposition peak was shifted with increasing amounts of levan. This new barrier polymer utilized a combination of time-dependent enzymatic mechanisms and can be considered promising for use in the coating of solid oral drugs for specific release.
- Subjects
FRUCTANS; MICROBIAL exopolysaccharides; ORAL medication; METHACRYLATES; PREBIOTICS; COPOLYMERS; DIFFERENTIAL scanning calorimetry
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2013, Vol 26, Issue 5, p943
- ISSN
1011-601X
- Publication type
Article