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- Title
Changes in plasma 1,25 and 24,25-dihydroxyvitamin D after renal transplantation in children.
- Authors
Garabedian, Michèle; Silve, Caroline; Levy-Bentolila, David; Bourdeau, Agnès; Ulmann, André; Nguyen, T. Minh; Lieberherr, Michèle; Broyer, Michel; Balsan, Sonia
- Abstract
The purpose of this investigation is to analyze changes in plasma 1,25-(OH)2D and 24,25-(OH)2D after successful renal transplantation in 20 children and young adults. Studies were performed on 8 subjects between the 1st and 10th month and on 12 others between the 20th and 30th to 36th month. Samples were assayed for plasma and urinary calcium, inorganic phosphate, creatinine, plasma bicarbonate, immunoreactive parathyroid hormone, 25-(OH)D, 24, 25-(OH)2D, and 1,25-(OH)2D concentrations. Results showed the following: (1) All subjects had normal or high plasma levels of dihydroxy-vitamin D metabolites. (2) In subjects with normal GFR's there was a significant inverse correlation between plasma 1,25-(OH)2D and phosphate concentrations and between plasma 1,25-(OH)2D concentrations and tubular reabsorption of phosphorus. (3) These correlations were not found in subjects with subnormal creatinine clearances (50 to 100 ml/min/1.73 m²) even though plasma 1,25-(OH)2D concentrations in these subjects were similar to those with normal creatinine clearances. (4) In subjects with subnormal creatinine clearances, an increase in plasma 1,25-(OH)2D concentrations to very high levels was observed during the first months following renal transplantation.
- Subjects
KIDNEY transplantation; PEDIATRIC nephrology; VITAMIN D; CALCIUM in the body; EXCRETION; URINE
- Publication
Kidney International, 1981, Vol 20, Issue 3, p403
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1981.153