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- Title
Impact of Preoperative Short‐Term Parenteral Nutrition Support on the Clinical Outcome of Gastric Cancer Patients: A Propensity Score Matching Analysis.
- Authors
Xu, Li‐Bin; Huang, Ze‐Xin; Zhang, Hui‐Hui; Chen, Xiao‐Dong; Zhang, Wei‐Teng; Shi, Ming‐Ming; Ma, Yu‐Ning; Shen, Xin‐Chen; Lin, Jiang‐Tao; Cai, Yi‐Qi; Shen, Xian
- Abstract
Objectives: Nutrition status is of great significance to the clinical outcome after major abdominal surgery. However, the effect of preoperative short‐term parenteral nutrition (PN) support among gastric cancer (GC) patients remains unknown and was evaluated in the current study. Methods: We retrospectively analyzed 455 nutritionally at‐risk GC patients after radical resection from 2010 to 2016. We matched patients with 3–7 days of PN support to those without PN support. χ2 And Mann‐Whitney U tests were used to compare differences between the PN and control groups. Results: The propensity‐matched sample included 368 GC patients (PN group, n = 184; control group, n = 184). The PN and control groups did not differ regarding postoperative complications (P =.528). The incidence of anastomotic leakage in the PN group was lower than in the control group (P =.011), whereas other complications were not found to differ between the groups. The hospitalization cost of the PN group was significantly higher than that of the control group (P <.001), whereas other outcome indicators were similar. Subgroup analysis showed that short‐term PN support may have an improved benefit for patients with serum albumin level <35 g/L, but not at the level of statistical significance (P =.17). Conclusion: Short‐term PN support did not significantly improve the short‐term clinical outcomes of nutritionally at‐risk GC patients, with the exception of a lower incidence of anastomotic leakage. Considering that short‐term PN support increases economic burden, PN should not be the preferred method among these patients.
- Subjects
PROPENSITY score matching; TREATMENT effectiveness; STOMACH cancer; DIET therapy; PARENTERAL feeding
- Publication
JPEN Journal of Parenteral & Enteral Nutrition, 2021, Vol 45, Issue 4, p729
- ISSN
0148-6071
- Publication type
Article
- DOI
10.1002/jpen.1944