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- Title
Protective Effect of Hispolon on Postoperative Cognitive Dysfunction in a Sevoflurane-Induced HT-22 Cell Model.
- Authors
Hua Wang; Yanan Ji; Chuanju Liu; Jie Gao; Junjiao Hu
- Abstract
Inhalation of the anesthetic sevoflurane leads to neuronal apoptosis, oxidative stress, and cognitive disorders, resulting in post-operative cognitive dysfunction. Hispolon, a natural polyphenol from Phellinus linteus, has been reported to exhibit anticancer, antidiabetic, antioxidant, antiviral, and anti-inflammatory activities. However, its functions in modulating sevoflurane-stimulated neuronal toxicity remain to be examined. To this end, using sevoflurane-treated HT22 cells as a model of postoperative cognitive dysfunction, we have examined the effect of hispolon. Our results show a diminution of the sevoflurane-induced rise in mitochondrial dysfunction, oxidative stress, cell toxicity, and apoptosis in HT22 cells by hispolon. In conclusion, these data suggest that hispolon may be a potential drug for treating postoperative cognitive dysfunction.
- Subjects
COGNITION disorders; POLYPHENOLS; ANTI-inflammatory agents; MITOCHONDRIAL pathology; SURGICAL complications; APOPTOSIS; HYPOGLYCEMIC agents; TREATMENT effectiveness; OXIDATIVE stress; SEVOFLURANE; CELL lines; MOLECULAR structure
- Publication
Current Topics in Nutraceutical Research, 2023, Vol 21, Issue 3, p260
- ISSN
1540-7535
- Publication type
Article
- DOI
10.37290/ctnr2641-452X.21:260-265