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- Title
OMEGA-3 FATTY ACIDS/VITAMIN E BEHAVE SYNERGISTICALLY ON ADIPONECTIN RECEPTOR-1 AND ADIPONECTIN RECEPTOR-2 GENE EXPRESSIONS IN PERIPHERAL BLOOD MONONUCLEAR CELL OF CORONARY ARTERY DISEASE PATIENTS.
- Authors
Ramezani, Atena; Djazayeri, Abolghasem; Koohdani, Fariba; Nematipour, Ebrahim; Javanbakht, Mohammad Hassan; Keshavarz, Seyed Ali; Golalizadeh, Ezzattollah; Fard, Ramin Mazaheri Nezhad; Djalali, Mahmoud
- Abstract
Reducing the levels of adiponectin receptors, AdipoR1 and AdipoR2 can reduce the ability of adiponectin in preventing inflammatory processes. Therefore, researches need to find a way to increase the gene expression of adiponectin receptors for the treatment of cardiovascular diseases. A randomized, double-blind, placebo controlled trial was conducted on 67 CAD male patients. Participants received 4g/day ?3 plus 400IU/day vitamin E (OE) or 4g/ day ?3 plus vitamin E placebo (OP) or both ?3 and vitamin E placebos (PP) for two months. The Gene expression of adiponectin receptors in PBMCs and serum high-sensitivity C-reactive protein in serum were measured. Consumption of omega-3 fatty acids significantly reduced the serum level of hsCRP as well as consumption of combined omega-3 fatty acids and vitamin E supplements. Gene expression of AdipoR2 significantly increased in OP and OE groups. Consumption of combined omega-3 fatty acids and vitamin E had a significant effect on the gene expression of AdipoR1. However, omega-3 fatty acids did not change the gene expression of AdipoR1 significantly. Administration of omega-3 fatty acids with or without vitamin E for two months results in significant increases in the gene expression of adiponectin receptors and hence improves serum levels of inflammatory process in CAD patients.
- Subjects
OMEGA-3 fatty acids; VITAMIN therapy; ADIPONECTIN; BLOOD cells; GENE expression; CORONARY heart disease treatment; CORONARY disease; RANDOMIZED controlled trials; PATIENTS
- Publication
Current Topics in Nutraceutical Research, 2015, Vol 13, Issue 1, p23
- ISSN
1540-7535
- Publication type
Article