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- Title
The Evolution and Recent Trends in Acoustic Targeting of Encapsulated Drugs to Solid Tumors: Strategies beyond Sonoporation.
- Authors
Honari, Arvin; Sirsi, Shashank R.
- Abstract
Despite recent advancements in ultrasound-mediated drug delivery and the remarkable success observed in pre-clinical studies, no delivery platform utilizing ultrasound contrast agents has yet received FDA approval. The sonoporation effect was a game-changing discovery with a promising future in clinical settings. Various clinical trials are underway to assess sonoporation's efficacy in treating solid tumors; however, there are disagreements on its applicability to the broader population due to long-term safety issues. In this review, we first discuss how acoustic targeting of drugs gained importance in cancer pharmaceutics. Then, we discuss ultrasound-targeting strategies that have been less explored yet hold a promising future. We aim to shed light on recent innovations in ultrasound-based drug delivery including newer designs of ultrasound-sensitive particles specifically tailored for pharmaceutical usage.
- Subjects
UNITED States. Food &; Drug Administration; TARGETED drug delivery; ULTRASOUND contrast media; POLYMERSOMES; NANOMEDICINE
- Publication
Pharmaceutics, 2023, Vol 15, Issue 6, p1705
- ISSN
1999-4923
- Publication type
Article
- DOI
10.3390/pharmaceutics15061705