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- Title
Comparison of the effects of thiopentone and propofol on the electrocardiogram of dogs.
- Authors
Dennis, S. .G.; Wotton, P. R.; Boswood, A.; Flaherty, D.
- Abstract
Sixty-four dogs were randomly assigned to receive either thiopentone or propofol and their electrocardiograms were recorded immediately before and shortly after they were anaesthetised. Thiopentone caused a marked increase in QT and JT intervals, a flattening of the T-wave and an increase in precordial QT dispersion. Propofol induced a less marked increase in QT and JT intervals, corrected for heart rate. Both agents induced an increase in heart rate and a decrease in heart rate variability, consistent with reduced vagal tone. Shortly after anaesthesia was induced, thiopentone affected ventricular repolarisation to a far greater extent than propofol, changes which suggest that it may be more likely to induce re-entrant ventricular arrhythmogenesis and could be associated with an increase in sympathetic tone. Propofol may therefore be more suitable than thiopentone for dogs with a susceptibility to ventricular arrhythmias or a long QT interval.
- Subjects
LABORATORY dogs; KETONES; ALCOHOL; ELECTROCARDIOGRAPHY; ANESTHESIA; HEART beat
- Publication
Veterinary Record: Journal of the British Veterinary Association, 2007, Vol 160, Issue 20, p681
- ISSN
0042-4900
- Publication type
Article
- DOI
10.1136/vr.160.20.681