We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Melatonin Improves Levels of Zn and Cu in the Muscle of Diabetic Obese Rats.
- Authors
Navarro-Alarcón, Miguel; Gil-Hernández, Fernando; Sánchez-González, Cristina; Llopis, Juan; Villalón-Mir, Marina; Olmedo, Pablo; Alarcón-Guijo, Pablo; Salagre, Diego; Gaona, Lorena; Paredes, Mario; Agil, Ahmad
- Abstract
Melatonin improves metabolic alterations associated with obesity and its diabetes (diabesity). We intend to determine whether this improvement is exerted by changing Zn and/or Cu tissue levels in liver, muscle, pancreas, and brain, and in internal (perirenal, perigonadal, and omentum) and subcutaneous lumbar white adipose tissues (IWAT and SWAT, respectively). Male Zücker diabetic fatty (ZDF) rats and lean littermates (ZL) were orally supplemented either with melatonin (10 mg/kg body weight/day) or vehicle for 6 weeks. Zn and Cu concentrations were not significantly influenced by diabesity in the analyzed tissues (p > 0.05), with the exception of Zn in liver. In skeletal muscle Zn and Cu, and in perirenal WAT, only Zn levels increased significantly with melatonin supplementation in ZDF rats (p < 0.05). This cytoplasmic Zn enhancement would be probably associated with the upregulation of several Zn influx membrane transporters (Zips) and could explain the amelioration in the glycaemia and insulinaemia by upregulating the Akt and downregulating the inhibitor PTP1B, in obese and diabetic conditions. Enhanced Zn and Cu levels in muscle cells could be related to the reported antioxidant melatonin activity exerted by increasing the Zn, Cu-SOD, and extracellular Cu-SOD activity. In conclusion, melatonin, by increasing the muscle levels of Zn and Cu, joined with our previously reported findings improves glycaemia, insulinaemia, and oxidative stress in this diabesity animal model.
- Subjects
WHITE adipose tissue; MELATONIN; OMENTUM; MEMBRANE transport proteins; OBESITY; EFFECT of stress on animals; SKELETAL muscle
- Publication
Pharmaceutics, 2021, Vol 13, Issue 10, p1535
- ISSN
1999-4923
- Publication type
Article
- DOI
10.3390/pharmaceutics13101535