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- Title
Efficacy and Safety of the Combination of Rituximab, Fludarabine, and Mitoxantrone for Rituximab-Naive, Recurrent/Refractory Follicular Non-Hodgkin Lymphoma With High Tumor Burden.
- Authors
Morschhauser, Franck; Mounier, Nicolas; Sebban, Catherine; Brice, Pauline; Solal-Celigny, Phillippe; Tilly, Herve; Feugier, Pierre; Fermé, Christophe; Copin, Marie Christine; Lamy, Thierry
- Abstract
The article evaluates the efficacy and safety of rituximab combined with intravenous fludarabine and mitoxantrone (R-FM) for patients with recurrent/refractory follicular non-Hodgkin lymphoma who had high tumor burden according to Groupe d'Etrude des Lymphomes Folliculaires (GELF). The results of the study revealed that the best overall response rate was achieved after four courses of R-FM, regardless of age, refractoriness to last previous therapy and score in Follicular Lymphoma International Prognostic Index (FLIPI).
- Subjects
CLINICAL drug trials; RITUXIMAB; FLUDARABINE; MITOXANTRONE hydrochloride; COMBINATION drug therapy; HODGKIN'S disease treatment; THERAPEUTICS
- Publication
Cancer (0008543X), 2010, Vol 116, Issue 18, p4299
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.25280