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- Title
Dendritic cells and IFN-α-producing cells are two functionally distinct non-B, non-monocytic HLA-DR<sup>+</sup> cell subsets in human peripheral blood.
- Authors
Chehimi, J.; Starr, S. E.; Kawashima, H.; Miller, D. S.; Trinchieri, G.; Perussia, B.; Bandyopadhyay, S.
- Abstract
At least two distinct HLA-DR+ cell subsets lacking surface markers specific for B cells, monocytes or other known lineages are present in human peripheral blood. One subset is non-adherent to plastic, produces interferon-alpha (IFN-α) when incubated with cytomegalovirus-infected target cells and provides an accessory function requited for natural killer (NK) cell-mediated lysis of such cells. These non-adherent HLA-DR+ cells express the surface antigen recognized by antibody anti-D44 and do not stimulate mixed leucocyte reaction (MLR). The other HLA-DR+ cell subset is loosely adherent to plastic, produces only minimal levels of IFN-α when incubated with cytomegalovirus-infected target cells and does not provide the accessory function required for NK cell-mediated lysis of such cells. These HLA-DR+ cells stimulate a strong MLR, do not express D44 antigen and meet the criteria of dendritic cells (DC) morphologically and functionally.
- Subjects
DENDRITIC cells; MONOCYTES; CYTOMEGALOVIRUSES; ANTIGEN presenting cells; LEUCOCYTES; IMMUNOLOGY
- Publication
Immunology, 1989, Vol 68, Issue 4, p486
- ISSN
0019-2805
- Publication type
Article