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- Title
TouchingBase.
- Authors
Harrington, Monica; Packer, Alan; Stebbins, Michael
- Abstract
The U.S. National Research Council and Institute of Medicine have issued a report recommending a series of organizational changes at the National Institutes of Health (NIH). Science students were most likely to be non-smokers, while law and medical students were most likely to be smokers and hence more likely to die of alcohol-related causes, accidents and suicide. The scid mutation is in Prkdc, which encodes the DNA-activated protein kinase (DNA-PK), catalytic subunit, an integral player in non-homologous end joining. Mutations of DNA-PK cause a deficiency in V(D)J recombination, resulting in a severely impaired ability to produce unique antigen receptors and thus an ineffective immune response. DNA-PK is several times more active in humans than in horses or mice, so mutations would probably be lethal.
- Subjects
UNITED States; ORGANIZATIONAL change; NATIONAL Institutes of Health (U.S.); RESEARCH institutes; SCIENCE students
- Publication
Nature Genetics, 2003, Vol 35, Issue 1, p17
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng0903-17