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- Title
Genes required for ionizing radiation resistance in yeast.
- Authors
Bennett, Craig B.; Lewis, L. Kevin; Karthikeyan, Gopalakrishnan; Lobachev, Kirill S.; Jin, Yong H.; Sterling, Joan F.; Snipe, Joyce R.; Resnick, Michael A.
- Abstract
The ability of Saccharomyces cerevisiae to tolerate ionizing radiation damage requires many DNA-repair and checkpoint genes, most having human orthologs. A genome-wide screen of diploid mutants homozygous with respect to deletions of 3,670 nonessential genes revealed 107 new loci that influence γ-ray sensitivity. Many affect replication, recombination and checkpoint functions. Nearly 90% were sensitive to other agents, and most new genes could be assigned to the following functional groups: chromatin remodeling, chromosome segregation, nuclear pore formation, transcription, Golgi/vacuolar activities, ubiquitin-mediated protein degradation, cytokinesis, mitochondrial activity and cell wall maintenance. Over 50% share homology with human genes, including 17 implicated in cancer, indicating that a large set of newly identified human genes may have related roles in the toleration of radiation damage.
- Subjects
GENES; SACCHAROMYCES cerevisiae; GAMMA rays
- Publication
Nature Genetics, 2001, Vol 29, Issue 4, p426
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng778