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- Title
Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load.
- Authors
Sanabani, Sabri Saeed; Youko Nukui; Pereira, Juliana; da Costa, Antonio Charlys; Soares de Oliveira, Ana Carolina; Pessôa, Rodrigo; Eudes Leal, Fabio; Segurado, Aluisio C.; Georges Kallas, Esper; Cerdeira Sabino, Ester
- Abstract
Background: The Interleukin 28B (IL28B) rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 (HTLV-1) proviral load (PvL) and the development of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Methods: In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects (81 HTLV-1 asymptomatic carriers, 24 individuals with HAM/TSP and 7 with Adult T cell Leukemia/Lymphoma (ATLL)). Results: All 112 samples were successfully genotyped and their PvLs compared. Neither the homozygote TT nor the heterozygote CT mutations nor the combination genotypes (TT/CT) were associated with a greater PvL. We also observed no significant difference in allele distribution between asymptomatic carriers and patients with HTLV-1 associated HAM/TSP. Conclusions: Our study failed to support the previously reported positive association between the IL28B rs12979860 polymorphisms and an increased risk of developing HAM/TSP in the Brazilian population.
- Subjects
GENETIC polymorphisms; GENETIC research; INTERLEUKIN-2; CELL-mediated lympholysis; THY-1 antigen
- Publication
BMC Infectious Diseases, 2012, Vol 12, Issue 1, p374
- ISSN
1471-2334
- Publication type
Article
- DOI
10.1186/1471-2334-12-374