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- Title
Polarized Th2 cells attenuate high-fat-diet induced obesity through the suppression of lipogenesis.
- Authors
Dong, Lijun; Gao, Jingtao; Yu, Lu; Liu, Shibo; Zhao, Yuxin; Zhang, Wen; Liang, Yinming; Wang, Hui
- Abstract
Immune cells, such as macrophages, B cells, neutrophils and T cell subsets, have been implicated in the context of obesity. However, the specific role of Th2 cells in adipose tissue function has remained elusive. Eight-week-old male CD3ε─/─ mice were randomly divided into two groups (≥ 5 mice per group): one received intravenous injection of Th2 cells isolated from LATY136F mice, while the other receiving PBS as a control. Both of groups were subjected to a high-fat diet (HFD). The adoptive transfer of polarized Th2 cells led to a significant reduction in obesity following a HFD. This reduction was accompanied by improvements in hepatic steatosis, glucose intolerance, and insulin resistance. Mechanistically, Th2 cell treatment promoted oxidative phosphorylation of adipocytes, thereby contributing to a reduction of lipid droplet accumulation. These findings suggest that Th2 cell therapy represents a novel approach for treating diet-induced obesity and other diseases involving lipid droplet accumulation disorders.
- Subjects
TH2 cells; LIPID synthesis; B cells; FAT cells; T cells; FATTY liver; ADIPOSE tissue diseases
- Publication
BMC Immunology, 2024, Vol 25, Issue 1, p1
- ISSN
1471-2172
- Publication type
Article
- DOI
10.1186/s12865-024-00598-z