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- Title
How does leptin restore euglycemia in insulin-deficient diabetes?
- Authors
Oberlin, Douglas; Buettner, Christoph
- Abstract
Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the JCI, Perry and colleagues provide evidence that suppression of lipolysis is a key facet of leptin-mediated restoration of euglycemia. However, more work remains to be done to fully understand the antidiabetic mechanisms of leptin.
- Subjects
PHYSIOLOGICAL effects of leptin; BLOOD sugar; TREATMENT of diabetes; TYPE 1 diabetes; INSULIN therapy; GLYCEMIC control; LEPTIN; ANIMALS; DIABETES; GENETIC disorders; LIPID metabolism disorders; THERAPEUTICS
- Publication
Journal of Clinical Investigation, 2017, Vol 127, Issue 2, p450
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI91880