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- Title
Single brain metastases from melanoma: remarks on a series of 84 patients.
- Authors
Salvati, Maurizio; Frati, Alessandro; D'Elia, Alessandro; Pescatori, Lorenzo; Piccirilli, Manolo; Pietrantonio, Andrea; Fazi, Maurizio; Santoro, Antonio
- Abstract
The authors report on 84 patients with single melanoma brain metastasis surgically treated from 1997 to 2007. There were 46 males and 38 females; mean age was 41 years (range 24-58 years). All patients were surgically treated, and 52 of them received postoperative adjuvant therapy consisting of whole-brain radiation therapy (36), radiosurgery (9), or a combination of these two techniques (7). Brain recurrences were observed in 44 cases, of which 9 were local. Of the latter, seven were re-operated while the remaining two were treated by radiosurgery. At 1-year follow-up, the survival rate was 52% (32 patients) whereas only 12 patients (14%) were still alive after 2 years. None of the patients in which removal was subtotal survived for more than 6 months after surgical treatment. Three years after the onset of the brain metastasis, five patients (6%) were still alive. Survival was significantly influenced by treatment with regard to overall survival reported in other series. A review of literature, together with our own series, suggests that radical surgical treatment of the lesion possibly employing the internal no-touch technique has significantly increased survival in our patients ( p < 0.05) and that the association of postoperative radiotherapy and re-operation in the event of recurrent metastatic lesions is advisable even though statistical significance was not reached ( p > 0.05).
- Subjects
BRAIN metastasis; MAGNETIC resonance imaging of the brain; SURVIVAL analysis (Biometry); RETROSPECTIVE studies; HEALTH outcome assessment
- Publication
Neurosurgical Review, 2012, Vol 35, Issue 2, p211
- ISSN
0344-5607
- Publication type
Article
- DOI
10.1007/s10143-011-0348-z