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- Title
Performance of Self-Collected Saliva Testing Compared with Nasopharyngeal Swab Testing for the Detection of SARS-CoV-2.
- Authors
Carrouel, Florence; Valette, Martine; Perrier, Hervé; Bouscambert-Duchamp, Maude; Dussart, Claude; Tramini, Paul; Bourgeois, Denis; Martinez-Sobrido, Luis; Almazan Toral, Fernando
- Abstract
The aim of this study was to determine whether self-collected pure saliva (SCPS) is comparable to nasopharyngeal (NP) swabs in the quantitative detection of SARS-CoV-2 by RT-PCR in asymptomatic, mild patients with confirmed COVID-19. Thirty-one patients aged from 18 to 85 years were included between 9 June and 11 December 2020. A SCPS sample and a NP sample were taken for each patient. Quantitative PCR was performed to detect SARS-CoV-2 viral load. Results of SCPS vs. NP samples testing were compared. Statistical analyses were performed. Viral load was significantly correlated (r = 0.72). The concordance probability was estimated at 73.3%. In symptomatic adults, SCPS performance was similar to that of NP swabs (Percent Agreement = 74.1%; p = 0.11). Thus, the salivary test based on pure oral saliva samples easily obtained by noninvasive techniques has a fair agreement with the nasopharyngeal one in asymptomatic, mild patients with a confirmed diagnosis of COVID-19.
- Subjects
SARS-CoV-2; SALIVA analysis; COVID-19; SALIVA; VIRAL load; ADULTS
- Publication
Viruses (1999-4915), 2021, Vol 13, Issue 5, p895
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v13050895