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- Title
pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol.
- Authors
Chin, Suk Fun; Romainor, Ain N. B.; Pang, Suh Cem; Lee, Boon Kiat; Hwang, Siaw San
- Abstract
Starch‐citrate samples with degrees of substitution (DS) ranging from 0.11 to 0.90 are synthesized by a green esterification reaction between citric acid and native sago starch (Metroxylon sagu) in an aqueous medium. Starch‐citrate nanoparticles with mean diameter of 105 nm are subsequently obtained by controlled precipitation through drop‐wise addition of dissolved starch‐citrate solution into excess absolute ethanol. These nanoparticles are observed to exhibit pH‐responsive release profiles within the physiological pH range of 1.2–8.6. The release profile of a model drug (paracetamol) is observed to obey the zero‐order kinetics, with the release mechanism based on the diffusion and swelling model. The cytotoxicity study in HaCaT cell lines (human skin cells) shows that starch‐citrate nanoparticles are non‐toxic and hence are suitable for biomedical applications as pH‐responsive drug carriers.
- Subjects
CITRATES; NANOPARTICLES; ACETAMINOPHEN; DRUG carriers; ETHANOL; CITRIC acid
- Publication
Starch / Staerke, 2019, Vol 71, Issue 9/10, pN.PAG
- ISSN
0038-9056
- Publication type
Article
- DOI
10.1002/star.201800336