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- Title
Clinical significance of EphA2 expression in squamous-cell carcinoma of the head and neck.
- Authors
Liu, Yong; Zhang, Xin; Qiu, Yuanzheng; Huang, Donghai; Zhang, Shuai; Xie, Li; Qi, Lin; Yu, Changyun; Zhou, Xiaojuan; Hu, Guoqing; Tian, Yongquan
- Abstract
Purpose: EphA2 receptor tyrosine kinase is frequently overexpressed and functionally altered in a variety of human cancers. The study aimed to assess EphA2 expression and to explore its roles in squamous-cell carcinoma of the head and neck (SCCHN). Methods: EphA2 expression in 98 primary SCCHN tissue specimens was analyzed by immunohistochemistry and correlated with clinicopathological parameters. Additionally, 13 paired SCCHN tissues and 6 SCCHN cell lines were evaluated for EphA2 expression by RT-PCR and immunoblotting. Results: EphA2 overexpressed in SCCHN tissues and SCCHN cell lines. More importantly, high EphA2 expression was significantly associated with tumor site, T classification, clinical stage, recurrence, and lymph node metastasis, respectively. Patients with high EphA2 expression had both poorer disease-free survival and overall survival than patients with low EphA2 expression. Multivariate Cox regression analysis revealed that EphA2 overexpression was an independent prognostic factor for patients with SCCHN. Conclusions: These findings suggested that EphA2 may contribute to SCCHN progression and represent a novel prognostic indicator for patients with SCCHN.
- Subjects
SQUAMOUS cell carcinoma; HEAD &; neck cancer treatment; PROTEIN-tyrosine kinases; GENE expression; IMMUNOHISTOCHEMISTRY; REVERSE transcriptase polymerase chain reaction; METASTASIS
- Publication
Journal of Cancer Research & Clinical Oncology, 2011, Vol 137, Issue 5, p761
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-010-0936-2