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- Title
Anti-CD20 treatment attenuates Th2 cell responses: implications for the role of lung follicular mature B cells in the asthmatic mice.
- Authors
He, Jilong; Li, Jingling; Lin, Qibin; Ni, Haiyang; Huang, Sisi; Cheng, Hong; Ding, Xuhong; Huang, Yi; Yu, Hongying; Xu, Yaqing; Nie, Hanxiang
- Abstract
Background: B cells were believed to act as antigen-presenting cells (APCs) to promote T helper type 2 (Th2) cell responses. However, the role of lung B cells and its subpopulations in Th2 cell responses in asthma remains unclear. Objective: We leveraged an anti-CD20 monoclonal antibody (mAb) treatment that has been shown to selectively deplete B cells in mice and investigated whether this treatment modulates Th2 cell responses and this modulation is related to lung follicular mature (FM) B cells in a murine model of asthma. Methods and results: We used a house dust mite (HDM)-induced asthma mouse model and found that anti-CD20 mAb treatment attenuates Th2 cell responses. Meanwhile, anti-CD20 mAb treatment did dramatically reduce the number of B cells, especially FM B cells in the lungs, but did not impact the frequency of other immune cell types, including lung T cells, dendritic cells, natural killer cells, and regulatory T cells in wild-type mice. Moreover, we found that the suppressive effect of anti-CD20 mAb treatment on Th2 cell responses could be reversed upon adoptive transfer of lung FM B cells, but not lung CD19+ B cells without FM B cells in asthmatic mice. Conclusions: These findings reveal that anti-CD20 mAb treatment alleviates Th2 cell responses, possibly by depleting lung FM B cells in a Th2-driven asthma model. This implies a potential therapeutic approach for asthma treatment through the targeting of lung FM B cells.
- Subjects
B cells; TH2 cells; KILLER cells; REGULATORY T cells; INTERLEUKIN-21; HOUSE dust mites
- Publication
Inflammation Research, 2024, Vol 73, Issue 3, p433
- ISSN
1023-3830
- Publication type
Article
- DOI
10.1007/s00011-023-01847-4