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- Title
宫颈高级别鳞状上皮内病变腺体受累和HPV感染对复发的影响.
- Authors
吴晨鹏; 李小华; 李雪梅; 樊智彬; 李君; 张志勇
- Abstract
Objective To evaluate the effect of glandular involvement and persistent human papillomavirus (HPV) infection upon the recurrence of high-grade squamous intraepithelial lesion (HSIL) of the cervix, aiming to provide evidence for postoperative clinical management. Methods Clinical data of 596 HSIL patients who underwent cold-knife conization were collected, including 240 cases of glandular involvement (glandular involvement group) and 356 cases of non-glandular involvement (nonglandular involvement group). The recurrence of HSIL at postoperative 2 years was considered as the end point. The differences between recurrent and non-recurrent patients were compared. According to glandular involvement and HPV-16 infection, patients were divided into the glandular involvement+ HPV-16 infection, glandular involvement alone, HPV-16 infection alone and non-glandular involvement+non-HPV-16 infection groups, respectively. The differences in the recurrence rate of HSIL were compared among four groups. Results Among 596 HSIL patients, 75 cases recurred (12.6%). HPV-16 infection rate in the glandular involvement group was 67.9%, significantly higher than 23.0% in the non-glandular involvement group, and the difference was statistically significant (P < 0.05). In univariate analysis, the proportion of~45 years old, glandular involvement and persistent HPV-16 infection were not significantly correlated with the recurrence of HSIL (all P > 0.05). The recurrence rates of HSIL were 33.8%, 10.9%, 8.5% and 9.7% in the glandular involvement+HPV-16 infection, glandular involvement alone, HPV-16 infection alone and non-glandular involvement+non-HPV-16 infection groups, respectively. The recurrence rate of HSIL in patients with glandular involvement+HPV-16 infection was significantly higher than that in other three groups, and the difference was statistically significant (all P < 0.017). Conclusions HSIL patients with glandular involvement and persistent HPV-16 infection are prone to relapse after cervical cold-knife conization. For these patients, active surgical regimen should be adopted and postoperative follow-up should be strengthened.
- Subjects
HUMAN papillomavirus; DISEASE relapse; POSTOPERATIVE care; UNIVARIATE analysis; INFECTION; CONIZATION
- Publication
Journal of New Medicine, 2023, Vol 54, Issue 5, p354
- ISSN
0253-9802
- Publication type
Article
- DOI
10.3969/j.issn.0253-9802.2023.05.010