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- Title
The mPer2 gene encodes a functional component of the mammalian circadian clock.
- Authors
Zheng, Binhai; Larkin, David W.; Albrecht, Urs; Zhong Sheng Sun; Sage, Marijke; Eichele, Gregor; Cheng Chi Lee; Bradley, Allan
- Abstract
Presents a report that assesses the in vivo function of mPer2 through the generation and characterization of a deletion mutation in the PAS domain of the mouse mPer2 gene. Shorter circadian period for the mutation display of mice homozygous; Diminution of the oscillating expression of both mPer1 and mPer2 in the suprachiasmatic nucleus; Indications that mPer2 might regulate mPer1 in vivo; Evidence that an mPer gene functions in the circadian clock.
- Subjects
GENES; CIRCADIAN rhythms; OSCILLATIONS; SUPRACHIASMATIC nucleus; BIOLOGICAL rhythms
- Publication
Nature, 1999, Vol 400, Issue 6740, p169
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/22118