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- Title
Current Understanding of the Role of the Quadruplets in Colorectal Cancer Biology - Osteoprotegerin and its Ligands RANK/RANKL/TRAIL.
- Authors
Tiiba, Jamal-Deen I.; Ahmadu, Peter Uchogu; Atiku, Adam; Tiah, Salifu Alhassan; Bugri, Amos Adapalala; Salifu, Musah; Laar, Elisha; Malechi, Hawa; Naamawu, Alhassan; Fuseini, Memunatu; Raymond, Anecham; Bacheyie, Peter P.; Abdulai, Mohammed Adam; Alidu, Issah; Alhassan, Ahmed; Hamid, Jemilatu G. Abdul; Yussif, Abukari; Tayawn, Patricia Terekuu; Sakyi, Abigail Asantewaa; Naa Yeng, Titus
- Abstract
Colorectal carcinoma (CRC) is one of the most prevalent forms of malignant tumors worldwide, with over 600,000 CRC-related deaths occurring annually. Despite major advances in surgical techniques and equipment, chemotherapy and radiation therapy, the prognosis for CRC patients remains poor because of distant metastasis and recurrence. Traditionally, the identification of patients at high risk of recurrence or distant metastasis has depended on pathological characteristics, such as depth of invasion, nodal metastasis, stage group and perforation or invasion of adjacent organs. However, the current tumor-node-metastasis (TNM) classification system is limited in that it cannot offer a prognosis for individual patients. To improve the outcome of patients with CRC, it is crucial to identify cancer-related genes that can serve as predictive and prognostic biomarkers to individualize therapy. Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor superfamily. It has been shown that OPG is involved in the development and progression of human malignancies. This review summarizes our current understanding of the role of OPG in fibrosis and will discuss its potential as a biomarker and/or novel therapeutic target for fibrosis.
- Subjects
QUADRUPLETS; COLORECTAL cancer; CANCER treatment; OSTEOPROTEGERIN; TUMOR necrosis factors
- Publication
Tropical Journal of Natural Product Research, 2023, Vol 7, Issue 1, p2087
- ISSN
2616-0684
- Publication type
Article
- DOI
10.26538/tjnpr/v7i1.1