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- Title
Roles of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis in bidirectional brain‐intestine interactions.
- Authors
Ide, Soichiro; Yamamoto, Ryuta; Suzuki, Hacchi; Takeda, Hiroshi; Minami, Masabumi
- Abstract
Aims: The bed nucleus of the stria terminalis (BNST) is a limbic structure mediating autonomic and neuroendocrine responses and negative affective states such as anxiety and fear. We previously demonstrated that noradrenergic transmission via β‐adrenoceptors within the ventral part of BNST (vBNST) is involved in bidirectional interactions between the brain and the upper gastrointestinal (GI) tract. The present study aimed to examine the roles of intra‐vBNST noradrenergic transmission via β‐adrenoceptors in bidirectional interactions between the brain and lower GI tract. Methods: In vivo microdialysis experiments were performed to examine colorectal distention (CRD)‐induced noradrenaline release within the vBNST of freely moving male Sprague‐Dawley rats. Colonic transit and abdominal pain perception were examined following intra‐vBNST injections of isoproterenol, a β‐adrenoceptor agonist, with and without co‐administration of timolol, a β‐adrenoceptor antagonist. Results: CRD increased extracellular noradrenaline levels within the vBNST and evoked abdominal contractions in a pressure‐dependent manner (30‐60 mm Hg). Bilateral intra‐vBNST injections of isoproterenol (30 nmol/side) significantly increased CRD (30 mm Hg)‐induced abdominal contractions. Intra‐vBNST injections of isoproterenol (30 nmol/side) significantly increased colonic transit, which was reversed by co‐administration of timolol (30 nmol/side). Conclusion: The results of this study suggest (a) the existence of a positive feedback loop between intra‐vBNST noradrenaline release and abdominal pain perception, and (b) the modulation of colonic motility by intra‐vBNST noradrenergic transmission via β‐adrenoceptors. Dysfunction of the lower GI tract may increase noradrenaline release within the vBNST, which, in turn, may exacerbate impairment of its motility and pain perception. In vivo microdialysis experiments demonstrated that colorectal distention (CRD) increased extracellular levels of noradrenaline within the vBNST. Intra‐vBNST injections of isoproterenol, a β‐adrenoceptor agonist, induced visceral hypersensitivity to CRD and increased colonic transit, and the increase in colonic transit was reversed by co‐administration of timolol, a β‐adrenoceptor antagonist. The present findings demonstrated important roles of noradrenergic transmission via β‐adrenoceptors within the vBNST in bidirectional brain‐intestine interactions.
- Subjects
NORADRENERGIC mechanisms; NEUROENDOCRINE system; GASTROINTESTINAL system; ADRENERGIC receptors; ABDOMINAL pain
- Publication
Neuropsychopharmacology Reports, 2018, Vol 38, Issue 4, p182
- ISSN
2574-173X
- Publication type
Article
- DOI
10.1002/npr2.12032