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- Title
Mucosal memory CD8<sup>+</sup> T cells are selected in the periphery by an MHC class I molecule.
- Authors
Huang, Yujun; Park, Yunji; Wang-Zhu, Yiran; Larange, Alexandre; Arens, Ramon; Bernardo, Iván; Olivares-Villagómez, Danyvid; Herndler-Brandstetter, Dietmar; Abraham, Ninan; Grubeck-Loebenstein, Beatrix; Schoenberger, Stephen P; Van Kaer, Luc; Kronenberg, Mitchell; Teitell, Michael A; Cheroutre, Hilde
- Abstract
The presence of immune memory at pathogen-entry sites is a prerequisite for protection. Nevertheless, the mechanisms that warrant immunity at peripheral interfaces are not understood. Here we show that the nonclassical major histocompatibility complex (MHC) class I molecule thymus leukemia antigen (TL), induced on dendritic cells interacting with CD8?? on activated CD8??+ T cells, mediated affinity-based selection of memory precursor cells. Furthermore, constitutive expression of TL on epithelial cells led to continued selection of mature CD8??+ memory T cells. The memory process driven by TL and CD8?? was essential for the generation of CD8??+ memory T cells in the intestine and the accumulation of highly antigen-sensitive CD8??+ memory T cells that form the first line of defense at the largest entry port for pathogens.
- Subjects
T cells; IMMUNOLOGIC memory; MAJOR histocompatibility complex; CELL differentiation; MOLECULES; DENDRITIC cells; EPITHELIAL cells
- Publication
Nature Immunology, 2011, Vol 12, Issue 11, p1086
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.2106