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- Title
CD98hc facilitates B cell proliferation and adaptive humoral immunity.
- Authors
Cantor, Joseph; Browne, Cecille D; Ruppert, Raphael; Féral, Chloé C; Fässler, Reinhard; Rickert, Robert C; Ginsberg, Mark H
- Abstract
The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell–specific deletion of the heavy chain of CD98 (CD98hc) resulted in lower antibody responses due to total suppression of B cell proliferation and subsequent plasma cell formation. Deletion of CD98hc did not impair early B cell activation but did inhibit later activation of the mitogen-activated protein kinase Erk1/2 and downregulation of the cell cycle inhibitor p27. Reconstitution of CD98hc-deficient B cells with CD98hc mutants showed that the integrin-binding domain of CD98hc was required for B cell proliferation but that the amino acid–transport function of CD98hc was dispensable for this. Thus, CD98hc supports integrin-dependent rapid proliferation of B cells. We propose that the advantage of adaptive immunity favored the appearance of CD98hc in vertebrates.
- Publication
Nature Immunology, 2009, Vol 10, Issue 4, p412
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.1712