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- Title
The Chemoselective Fischer's Synthesis of Indolenine Derivatives By iso-Butyric Acid As A Weak Organic Acid Catalyst.
- Authors
Sajjadifar, S.; Amini, I.; Navabi, Z.; Jabbari, H.; Pouralimardan, O.
- Abstract
Iso-butyric acid as a new, simple, and expensive solvent/catalyst was successfully used for the chemoselective Fischer's synthesis of indolenines derivatives 3a-r by onepot condensation reaction of various phenylhydrazines 1a-e with the substituted acetophenones 2a-c at reflux conditions. In this protocol, all products 3a-r were obtained in high yields and short reaction time. The structures of the product were established with spectroscopic data of 1H NMR, 13C-NMR, and FT-IR.
- Subjects
BUTYRIC acid; PHENYLHYDRAZINE; ACETOPHENONE; REACTION time; ORGANIC acids
- Publication
Journal of Sciences, Islamic Republic of Iran, 2019, Vol 30, Issue 2, p129
- ISSN
1016-1104
- Publication type
Article