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- Title
Fever prophylaxis can reduce vaccine responses: A caution.
- Authors
Scheifele, David; Ward, Brian
- Abstract
Prophylactic administration of antipyretic/analgesic drugs, started at the time of immunization and repeated 6 and 12 hours later, is sometimes undertaken to reduce postimmunization fever and irritability in infants. Two recent studies showed that such prophylaxis can reduce immune responses to some infant vaccines, warranting judicious use. In contrast, implementing treatment 6 hours or more after immunization had no effect on vaccine responses and would reduce drug exposure of asymptomatic infants.
- Subjects
FEVER; ACETAMINOPHEN; CHEMOPREVENTION; IMMUNITY; IMMUNIZATION; VACCINES; IBUPROFEN; NONOPIOID analgesics; PREVENTION
- Publication
Paediatrics & Child Health (1205-7088), 2018, Vol 23, Issue 4, p245
- ISSN
1205-7088
- Publication type
Article
- DOI
10.1093/pch/pxy011