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- Title
舒血宁注射液联合硝酸酯类药物治疗冠心病心绞痛的有效性及安全性的系统评价.
- Authors
张洁洁; 袁 漂; 孟 伟; 李金根
- Abstract
OBJECTIVE: To systematically review the efficacy and safety of Shuxuening injection combined with nitrates in the treatment of angina pectoris of coronary heart disease. METHODS: Databases of CNKI, Wanfang Data, VIP, CBM, PubMed, Embase, the Cochrane Library and Web of Science were retrieved, with the retrieval time from the establishment of the database to Mar. 2022, the published randomized controlled trials of Shuxuening injection combined with nitrates (observation group) contrasted with nitrates alone (control group) in the treatment of angina pectoris of coronary heart disease were enrolled according to the literature inclusion criteria, so that the data was extracted. The risk bias wvaluation was conducted by using Cochrane system evaluator manual 5. 1. 0, the clinical efficacy and safety were evaluated by using RevMan 5. 3 software. RESULTS: A total of 19 studies were enrolled, including 2 250 patients ( 1 145 cases in the observation group and 1 105 cases in the control group), and the literature quality was general. Results of Meta-analysis showed that compared with using nitrates alone, Shuxuening injection combined with nitrates in the treatment of angina pectoris of coronary heart disease had significantly efficacy for the clinical symptoms of angina pectoris, more significant reduction in the whole blood viscosity, plasma viscosity, fibrinogen and platelet adhesion rate, more significantly improvement in ECG abnormality, with statistically significant differences (P<0. 01). Only three studies reported adverse drug reactions, and the difference in the incidences of adverse drug reactions between two groups was not statistically significant (P = 0. 19). CONCLUSIONS: Shuxuening injection combined with nitrates in the treatment of angina pectoris of coronary heart disease can improve the clinical efficacy and ECG abnormality, reduce the whole blood viscosity, plasma viscosity, fibrinogen level and platelet adhesion rate.
- Subjects
ANGINA pectoris; NITROGLYCERIN
- Publication
Evaluation & Analysis of Drug-Use in Hospitals of China, 2023, Issue 11, p1350
- ISSN
1672-2124
- Publication type
Article
- DOI
10.14009/j.issn.1672-2124.2023.11.016