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- Title
Copper-Containing Nanosystems Based on Macromolecular Hydrophilic Stabilizers.
- Authors
Valueva, S. V.; Nazarova, O. V.; Vylegzhanina, M. E.; Borovikova, L. N.; Zolotova, Yu. I.; Panarin, E. F.
- Abstract
An original method for the synthesis of copper-containing nanosystems for biomedical applications using hydrazine hydrate as a reducing agent was developed. The process involves intermediate formation of the [Cu(NH3)4]2+ complex ion, which ensures the formation of Cu0 nanoparticles without oxide impurity. The 2-deoxy-2-methacrylamido-D-glucose copolymer with 2-(dimethylamino)ethyl methacrylate or bovine serum albumin was used as a macromolecular hydrophilic stabilizer. The spectral and structure-morphological characteristics of the nanosystems were studied. This stabilization resulted in an almost unimodal distribution of zerovalent copper nanoparticles in aqueous solutions due to their rather good shielding by macromolecules.
- Subjects
SERUM albumin; COMPLEX ions; REDUCING agents; AQUEOUS solutions; MACROMOLECULES; HYDRAZINE derivatives
- Publication
Doklady Chemistry, 2019, Vol 489, Issue 1, p264
- ISSN
0012-5008
- Publication type
Article
- DOI
10.1134/S0012500819110065