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- Title
Exploring the anti‐cancer potential of dietary phytochemicals for the patients with breast cancer: A comprehensive review.
- Authors
Sohel, Md; Aktar, Suraiya; Biswas, Partha; Amin, Md. Al; Hossain, Md. Arju; Ahmed, Nasim; Mim, Md. Imrul Hasan; Islam, Farhadul; Mamun, Abdullah Al
- Abstract
Background: The most common and deadly cancer in female is breast cancer (BC) and new incidence and deaths related to this cancer are rising. Aims: Several issues, that is, high cost, toxicity, allergic reactions, less efficacy, multidrug resistance, and the economic cost of conventional anti‐cancer therapies, has prompted scientists to discover innovative approaches and new chemo‐preventive agents. Materials: Numerous studies are being conducted on plant‐based and dietary phytochemicals to discover new‐fangled and more advanced therapeutic approaches for BC management. Result: We have identified that natural compounds modulated many molecular mechanisms and cellular phenomena, including apoptosis, cell cycle progression, cell proliferation, angiogenesis and metastasis, up‐regulation of tumor‐suppressive genes, and down‐regulation of oncogenes, modulation of hypoxia, mammosphere formation, onco‐inflammation, enzymatic regulation, and epigenetic modifications in BC. We found that a number of signaling networks and their components such as PI3K/Akt/mTOR, MMP‐2 and 9, Wnt/‐catenin, PARP, MAPK, NF‐κB, Caspase‐3/8/9, Bax, Bcl2, Smad4, Notch1, STAT3, Nrf2, and ROS signaling can be regulated in cancer cells by phytochemicals. They induce up‐regulation of tumor inhibitor microRNAs, which have been highlighted as a key player for ani‐BC treatments followed by phytochemical supplementation. Conclusion: Therefore, this collection offers a sound foundation for further investigation into phytochemicals as a potential route for the development of anti‐cancer drugs in treating patients with BC.
- Subjects
BREAST cancer; CANCER patients; PHYTOCHEMICALS; CANCER cell growth; MULTIDRUG resistance; CELL cycle
- Publication
Cancer Medicine, 2023, Vol 12, Issue 13, p14556
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.5984