We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
B-cell receptor signaling derailed in lymphomas.
- Authors
Klein, Ulf; Pasqualucci, Laura
- Abstract
In this article the authors discuss the study about B-cell receptor (BCR). They state that an antigen that triggers the BCR provides a critical growth signal in the multistep process of lymphomagenesis as based on the characteristics of the reaaranged immunoglubin genes expressed by the tumor cells. They cite the study of R. E. Davis which data offers rationale for the development of targeted therapies aimed at inhibiting BCR signaling in this lymphoma subtype.
- Subjects
B cells; ANTIGENS; TUMORS; DAVIS, R. E.; LYMPHOMAS; THERAPEUTICS
- Publication
Immunology & Cell Biology, 2010, Vol 88, Issue 4, p346
- ISSN
0818-9641
- Publication type
Opinion
- DOI
10.1038/icb.2010.36